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Diet composition appeared to account for several of the observed microbiome differences
This reaction has two metabolic consequences: it consumes SAM (the body's universal methyl donor) and it diverts nicotinamide away from the NAD+ salvage pathway
The most common side effects are injection-site soreness (41%, lasting 24-36 hours), mild nausea (12-15%, lasting 4-8 hours), and skin flushing (8-10%, lasting 10-30 minutes)