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Traditionally, they have been studied in isolation, but a burgeoning body of evidence now positions them as manifestations of a shared systemic age-associated metabolic dysfunction ( 2 Sarcopenia and metabolic mechanism Sarcopenia is a multifactorial syndrome driven by a complex interplay of metabolic dysregulations that create a self-perpetuating cycle of muscle wasting ( This metabolic dysfunction is exacerbated by inflammaging, characterized by elevated pro-inflammatory cytokines such as TNF-, IL-6, and C-reactive protein (CRP) ( Mitochondrial dysfunction is another key pillar of sarcopenia
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Phenotypic analysis showed that PGC numbers in Trim28 cko embryos were normal at E8.5 but decreased from E9.5 to E12.5 (Fig
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