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Interaction with Strong CYP3A4/5 Inhibitors Strong CYP3A4/5 inhibitors can increase plasma concentrations of saxagliptin, potentially enhancing its pharmacological effects and adverse reactions

Metabolism 1978

[24] Finally, a 2020 Cochrane systematic review found insufficient evidence to suggest that metformin monotherapy reduced all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, or end-stage renal disease when compared to DPP-4 inhibitors for the treatment of type 2 diabetes

Davies M, Pratley R, Hammer M, Thomsen AB, Cuddihy R

This doesnt mean you should avoid exercising on a GLP-1

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