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The opening line calling them controlled prescription drugs compounds the same mistake

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14,15,16 In addition to oxidative stress, there is a disruption of glutamate homeostasis during opioid withdrawal resulting in an increase in synaptic glutamate (excitatory neurotransmitter) that leads to increased neuronal firing

This suggests the enzyme plays an active role in maintaining obesity, not just responding to it

The muscle loss is not due to direct drug toxicity but rather to the metabolic consequences of significant caloric restriction