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Individuals with pre-existing conditions or those on specific drugs should seek advice from a healthcare provider before incorporating it into their routine
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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
PMID: 36899852
Recovery athletic and clinical-interest discussion often centers on recovery and tissue repair, again largely extrapolated from GH physiology rather than demonstrated in well-controlled trials of these peptides
The principal changes are as follows: GHK-Cu for non-injectable routes of administration is being removed from Category 1, and GHK-Cu for injectable routes of administration is separately being removed from Category 2
