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This peptidergic interaction sheds light on the fine control of feeding regulation

Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin

Front Cardiovasc Med (2022) 9:922441

Unlike -MSH, KPV does not activate pigment-related enzymes such as dopa oxidase, so its anti-inflammatory effects are separate from skin pigmentation

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These two structural changes significantly reduce binding to IGF-binding proteins (IGFBP) , which translates into more of the free, active form of the peptide and a distinctly longer action