The principles of transdermal drug delivery are well-established in pharmaceutical science: The skins barrier function limits the passive diffusion of most compounds Molecules generally need to be below 500 Daltons and have balanced lipid/water solubility properties Therapeutic concentrations of active ingredients must be achievable through the limited surface area of a patch For context, successful medical transdermal patches (like nicotine or hormone delivery systems) utilise compounds selected explicitly for their transdermal permeability characteristics and are developed through extensive pharmaceutical research
While effective, this approach carries risks including supraphysiological hormone levels, suppression of natural GH production, and side effects such as fluid retention, joint pain, carpal tunnel syndrome, and potential insulin resistance
;11(2) Kaplan A, Heatley H, Townend J, Skinner D, Carter V, Hubbard R et al (2025) The Real-World impact of Glucagon-Like peptide 1 receptor agonists on asthma control in people with High-Risk asthma and obesity
doi: 10.1111/dom.13129 18 KamruzzamanMHorowitzMJonesKLMaratheCS
These medications mimic the effects of a natural hormone that regulates blood sugar and appetite, making them powerful tools in comprehensive weight management programs
Recovery from physical activity remains enhanced, allowing consistent exercise programming