As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]
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Similarly, cardiovascular benefits independent of GLP-1R activation have also been demonstrated [38]
10.1073/pnas.1411131111 Proc
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