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Quick Answer: GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, but some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, significant weight loss, or dehydration from gastrointestinal side effects

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This stuff can get REALLY complicated, even beyond what I can dissect, but the short story is that when GLP-1 levels increase they activate circuitry in the brain that makes us want to eat less

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