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If you are currently on Zepbound: If you tolerate it well and are responding (weight loss tracking with expected curve, no side effects derailing therapy), there is no clinical reason to switch when orforglipron approves
Schibler U (2020)
It plays an essential role in cellular energy production by transporting long-chain fatty acids into the mitochondria, where they undergo beta-oxidation to generate adenosine triphosphate (ATP)
they are widely distributed throughout the central nervous system and the peripheral tissues, including the gastrointestinal tract
After GLP-1 medications, these growth hormonestimulating peptides have become some of the most sought-after compounds in the United States
In parallel, emerging evidence suggests that the range of action of GLP-1 on reward behavior is not limited to food-derived reward but extends to cocaine, amphetamine, and alcohol reward
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