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Monitoring-guided supplementation is the usual approach, typically beginning with oral supplementation if blood tests indicate suboptimal levels, and escalating to IM injection if oral treatment is insufficient or poorly tolerated

Commonly investigated in dermatology and biomaterials research, AHK-Cu is used in models focused on collagen/elastin dynamics, inflammatory signaling balance, and oxidative-stress response

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A widely cited study by Kraus and colleagues used genetic knockdown in mice