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It is a non-selective agonist of MC1R, MC3R, MC4R, and MC5R with preferential activity at MC3R/MC4R

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The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and 3-AR Knock-Out Mice, Mark Heffernan, Roger J

Participants were randomized in a 1:1 ratio to receive either placebo or semaglutide (2.4 mg maximal dose, achieved over a 16-weeks ramp from a starting dose of 0.24 mg) once weekly by subcutaneous injection for a mean duration of 34.213.7 months

**Common 5mg vial doses:** - 0.25mg starting dose 0.05mL 5 insulin units (lasts ~20 weeks per vial) - 0.5mg dose escalation 0.10mL 10 units - 1.0mg therapeutic dose 0.20mL 20 units - 2.4mg maximum (Wegovy equivalent) 0.48mL 48 units ## How to Reconstitute Other Semaglutide Vial Sizes ### 10mg Semaglutide Vial The 10mg vial provides better economy and fewer vial changes

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