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Now, there is a lack of large-scale, long-term clinical trials evaluating its safety parameters and productivity in humans for this specific indication

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However, after initial sensitivity, many patients develop resistance to treatment 42,43

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YSHS can regulate the blood sugar and lipid levels of DKD rats, alleviate the symptoms of IR and podocyte reduction, and is conducive to the repair of GFB function, possibly correlated with the increase of nephrin and podocin protein levels and the decrease of platelet-derived growth factor receptors (PDGFR) protein levels (116)

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