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NICE recommends Saxenda only within specialist weight management services (Tier 3 or 4) for adults meeting specific BMI and comorbidity criteria

The safety profile of retatrutide is similar to other incretin-based therapies, with the most commonly reported adverse events being transient and mostly mild to moderate gastrointestinal symptoms, with the 4 mg starting dose group having a higher incidence than the 2 mg starting dose group

doi: 10.1155/2023/4365895 11 WeiJLuXBaoXZhangCLiJRenCet al

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This comparison aims to assist patients and healthcare providers in making informed decisions based on individual preferences and clinical needs

There are a couple of possible mechanisms for this