Elbows and knees
Secombe WD, James L, Hahn P & Jones E (1987): L-Carnitine trearment in the hyperlipidemic rabbit
Breaks make sense for users experiencing treatment plateau where benefits cease increasing despite continued application suggesting diminishing returns from ongoing use, comfortable with some benefit decline during off periods accepting fluctuation in skin quality, budget-conscious seeking to minimize annual treatment costs through intermittent purchasing, philosophically preferring avoiding indefinite dependency on any skincare product, planning life changes incompatible with consistent application (extended travel, relocation, financial shifts), and wanting to assess whether improvements prove durable or require continuous maintenance before committing to indefinite treatment
Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)
Cells in the body make glutathione to protect themselves from oxidative stress
These subtypes often coexist in the same patient, making the identification and treatment of a single causative agent or etiology quite challenging [1,2,3,4]