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The practical difference is simple
Oral B12 supplements require intrinsic factor a glycoprotein produced in the stomach to be absorbed through the ileum
Designs for Health build theirs liposomally so a meaningful amount actually reaches your cells, to the practitioner-grade standard the brand is known for
Anaphylaxis, peripheral neuropathy, hepatotoxicity, thyroid dysfunction, renal stress, injection-site infections, and zinc depletion all documented in peer-reviewed literature
10.3389/fphar.2015.00071 Front
doi: 10.1016/j.clinthera.2020.07.017
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