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At 48 weeks, participants on the 8 mg dose achieved a mean body weight reduction of 22.8%, while those on the highest 12 mg dose achieved a mean reduction of 24.2% compared to just 2.1% in the placebo group

lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy

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The researchers also found that semaglutide users with depression had a 44% lower risk, while those with anxiety disorders had a 38% lower risk

Sexual side effects are underreported precisely because patients feel awkward bringing them up

Semaglutide mimics this hormone and tells the brain when the body is full much faster