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From a public health perspective, there is an increasing body of evidence highlighting a new area of research

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Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

These findings support the hypothesis that the cardiometabolic benefits of GLP-1RA and SGLT2i may be additive and suggest combination therapy could lead to better clinical outcomes

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10.1152/physrev.00013.2014 72 SaxenaA