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Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status
IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation
shield from moisture and light [11] [12]
This creates a vicious cycle: the immune response causes oxidative stress, and the oxidative stress triggers even more immune activity
(Updated 2021 Aug 14)
PubMed laboratory research record [PMID: 984142] PubMed record related to this compound for laboratory literature review
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