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Very high baseline A1C and long-standing diabetes Pre-existing diabetic retinopathy or macular edema Concurrent insulin therapy Large and rapid A1C reductions over a short period Additional vascular risks such as high blood pressure, high cholesterol, kidney disease, or sleep apnea Improving glucose control remains important for long-term eye health

the trade-off would be the common adverse effects of hypoglycemia and weight gain

Such neuronal changes, or lesions, are characterized by tangles of nerve fibers and the increased presence of -amyloid and hyperphosphorylated tau in the brain, which ultimately leads to a decline in nervous system function

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The second generation, like Wegovy and Zepbound, hit 25% or more on average with just one shot a week