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The MHRA has not approved any GLP-1 receptor agonist for use below the labelled doses, and this approach falls outside current prescribing guidelines

You need sufficient protein and vitamins and all the compounds where there is a risk of shortage because of the decreased food intake and it is a major decrease in appetite and food intake

This approach helps identify which supplement may be responsible if side effects occur

People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use GLP-1 receptor agonists because of potential tumor risks observed in animal studies

Support groups, either in-person or online, can help process the identity changes that accompany significant weight loss

Retatrutide is currently in phase 3 clinical trials and has not yet been approved by the U.S