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Accordingly, studies in rodents have demonstrated the ventral tegmental area and nucleus accumbens mediate the effects of GLP-1RAs on alcohol intake 11,12,55

Those who choose to ignore this principle often overlook additional nutritional factors like food allergies/intolerances, short and long term satiety, neurological reward (aka dopamine response), palatability (taste, smell, texture, etc.), and metabolic (in)flexibility

It works as part of an "ileal brake" mechanism to signal satiety and fullness to the brain, thus reducing food intake

Many patients also report struggling with anxiety or depression, particularly when injuries result in permanent physical changes or limitations

In cases of IBS-D foods that contain high levels of insoluble fiber, such as wholemeal breads and whole grains, should be avoided, along with caffeine and carbonated drinks, which exacerbate symptoms