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3 Placebo-controlled trials confirm that topical tretinoin 0.05-0.1% significantly smooths wrinkles, lightens mottled pigmentation, and increases collagen production between three and 12 months across diverse phototypes, with benefits persisting beyond one year

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Green flags in the article are posts that reference peer-reviewed studies, acknowledge that outcomes vary between individuals, and emphasize provider involvement rather than working around it

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