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Annu Rev Physiol 78:277299

Its high in protein plus contains probiotics from the yogurt to support the gut microbiome

Br J Pharmacol 101: 527530

Melatonin also activates the mitochondrial autophagy pathway: upregulating expression of PINK1/Parkin and the autophagy marker LC3 results in the degradation of damaged mitochondria (decreased P62 expression) and the maintenance of mitochondrial health [121]

This means they have not been formally assessed for safety, efficacy, or quality by the Australia's medicines regulator (6)

Biologic-nave obese patients appear to derive the greatest benefit, while those already on IL-17 or IL-23 inhibitors show more modest additive effects, consistent with a predominantly weight-lossmediated mechanism