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Secondary concerns include altered perception of medication tolerance (cannabis-induced appetite suppression mimicking drug efficacy), reduced motivation for healthy lifestyle changes that enhance GLP-1 outcomes, and potential delayed medical evaluation if serious adverse events occur

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Greater waist circumference reduction at week 20 was associated with lower subsequent MACE risk, suggesting that reduction in central adiposity (visceral fat around the organs) may contribute to cardiovascular protection

Iorga, R.A., et al., Metabolic and cardiovascular benefits of GLP-1 agonists, besides the hypoglycemic effect (Review)

The pineal-axis findings link the compound to circadian-rhythm research and to broader pineal-gland-aging research framings