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Common Side Effects: Nausea and Vomiting : Frequently occurs when starting semaglutide or increasing the dose Diarrhea: Common during the initial phase of treatment Constipation : Affects some patients during treatment Abdominal Pain : This may occur, often mild to moderate Headache : This can occur, especially at the start of treatment Fatigue : Ensure sufficient rest and a balanced diet

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There is currently no established pharmacological mechanism by which tirzepatide would be expected to cause or exacerbate RLS symptoms

(PubMed) Moura FA, de Andrade KQ, dos Santos JC, Goulart MO