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Similarly, secretin, although less studied for weight loss, regulates digestion, fat absorption and digestion, that may provide broader benefits for metabolic therapies

Common adverse effects of Ozempic include: Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation) usually mild to moderate and diminishing over time Injection site reactions Hypoglycaemia (particularly when used with insulin or sulfonylureas) More serious but less common adverse effects include: Pancreatitis if suspected, stop treatment and seek immediate medical attention if experiencing severe, persistent abdominal pain Diabetic retinopathy complications regular eye examinations are recommended Gallbladder disease including cholelithiasis and cholecystitis

Renal and Metabolic Benefits The benefits of GLP-1 agonists extend to renal outcomes, as demonstrated in the SELECT trial

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(9) Rudolphi B, et al