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Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 2008

These opposing effects might seem like they would cancel each other out

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Briefly, 3 g of each protein sample was mixed with 15 L of 50 mM ammonium bicarbonate (pH 7.8) (Thermo Fisher Scientific), followed by protein reduction with 2 L of 100 mM dithiothreitol (Thermo Fisher Scientific) for 30 min and protein alkylation with 5 L of 2-iodoacetamide (Thermo Fisher Scientific) for an additional 30 min at room temperature in the dark

Crucially, it has the extraordinary ability to regenerate and recycle other endogenous antioxidantssuch as glutathione, Vitamin C, and Coenzyme Q10back into their active states after they have been depleted, ensuring a continuous, robust defense against cellular damage

Real-world evidence from UK and European databases suggests that patients with type 2 diabetes and fatty liver who receive GLP-1 therapy experience improvements in liver enzyme levels (ALT, AST) and non-invasive markers of fibrosis