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(3,4) Creatine influences muscle tissue in several ways, and multiple mechanisms have been suggested to explain the enhanced exercise performance observed after creatine intake: Optimizing energy metabolism by maintaining higher levels of the body's energy currency, adenosine triphosphate or ATP (5) Promoting protein metabolism in muscle cells (6,7) Inhibiting tissue damage by inhibiting oxidative stress (2,6,8) Creatine benefits with aging Multiple clinical studies have shown that creatine positively impacts strength, body composition, and muscle performance in older adults, particularly when combined with resistance training

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Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

Proc Natl Acad Sci US A 101:33813386