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For example, there are other drugs in this class, liraglutide, that about six years ago showed also very promising results But you cant really go deep on this paper without doing a little bit of background on what GLP-1 is because this drug (semaglutide) is effectively just an analog of GLP-1 Key background on insulin, glucagon and the incretin effect to appreciate the effects of semaglutide [4:00] This first discussion is a prologue to make sure that we understand how semaglutide works Looking through the lens of what is an incretin?, or what is the incretin effect? Only when you can measure insulin can you understand what the incretin effect is Effectively, it comes down to a bit of a mismatch between how oral and intravenous glucose are processed Taking a step back Insulin and glucagon are two hormones that you have to really understand to get what incretins are and then by extension to appreciate what semaglutide is doing -What is insulin