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In chronic weight management, GLP-1 medications are sometimes used in conjunction with a low-calorie diet and increased physical activity

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NICE guidance TA1026 supports a personalised approach to dose management rather than a fixed escalation schedule

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It is the regime associated with these substances which is fraught with problems

Gastrointestinal Adverse Reactions The incidences of pre-selected gastrointestinal adverse experiences in patients treated with sitagliptin and metformin were similar to those reported for patients treated with metformin alone