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These medications should also be used cautiously in individuals with certain medical conditions, such as epilepsy, untreated hypothyroidism, obesity, hyperglycemia, or elevated levels of plasma fatty acids, as these conditions may increase the risk of adverse effects or alter the drugs response

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

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Disruptions in cerebral perfusion, whether due to trauma, ischemia, or hemorrhage, are well-established drivers of acute neuronal injury

Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis

Mol Ther Nucleic Acids