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Understanding potential causes and management strategies can help ensure safe, effective treatment whilst minimising discomfort

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In addition to its direct effects on beta cells, GIP also leads to increased glucagon secretion, and indirectly results in increased insulin secretion via communication between the alpha and beta cells of the pancreas ( via complex mechanisms, including stimulation of somatostatin secretion, which inhibits glucagon secretion, and indirectly via stimulation of insulin production, which then inhibits glucagon release ( Figure 1 Incretin action plays a large role on post-prandial secretion of insulin, and may account for up to 70% of hormone release ( Both incretins have effects outside the pancreas

Its unclear if observed fractures relate more to rapid fat loss than to a direct pharmacologic effect

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They seldomly suffer from lipid peroxidation and subsequent ferroptosis originating from oxidative phosphorylation 49