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7 Aditionaly risk factors for drug-induced nephrotoxicity include patient-specific factors (age and sex), 8 kidney-specific factors (high exposure to drugs/metabolites), 5 and drug-specific factors (high doses, prolonged use)

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However, that is not always the case

TECs, key components of the kidney, are vulnerable to physical and chemical damage, including hypoxia, toxins, proteinuria, metabolic diseases, and senescence [4]

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