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What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

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The injuries most commonly alleged include gastroparesis (stomach paralysis), intestinal obstruction, severe and persistent nausea and vomiting, aspiration pneumonia related to impaired gastric motility, and complications arising from nutritional deficiencies caused by an inability to eat normally

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