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Hyperglycemia has been shown to negatively regulate FoxO1 expression and paralleled loss of insulin content 22
Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema
Sassone-Corsi, M
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