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Mechanosensitivity of cancer cells in contact with soft substrates using AFM

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As the microneedles create tiny micro-channels in the skin, the RF energy heats the underlying layers, stimulating a natural wound-healing response that triggers new collagen and elastin production

18 These findings argue against a purely diffusible extracellular mediator and instead point toward a mechanism that depends on direct membrane proximity

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MGF: Minimal reported adverse effects in preclinical studies