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GIP and GLP-1 are both degraded very quickly by dipeptidyl peptidase 4 (DPP4) [57,58,59], making analogues of these endogenous hormones poor drug candidates

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Recent studies suggest that senescent glial cells also produce SASP-like molecules

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In the case of obesity, the weight loss effects dont come from the gut but originate in the brain

Epidemiological evidence indicates that cardiovascular disease and neurodegenerative processes shares similar aspects, in term of prevalence, age distribution, and mortality