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On game days, the morning injection occurs 4-6 hours before play

doi: 10.1016/j.neuron.2014.12.007, 108 PizzorussoT.BerardiN.MaffeiL

What followed was nearly two decades of research chasing the receptor that GHRP-6 was activating, a pursuit that eventually led to the identification of ghrelin as the endogenous GHSR-1a ligand in 1999

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This was only partially rescued by supplementation of B 12 , indicating that the microbiota plays additional roles in driving this process