For each pancreas, 3 sections 150 m apart from each other were stained for insulin
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Age- and tissue-dependent modulation of igf-1/pi3k/akt protein expression by dietary restriction in mice
Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig