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Different methods are applied depending on whether the sample is biological (e.g., plasma, urine, tissue) or food-based

For comparisons across multiple time points, a two-way repeated measures ANOVA with Geisser-Greenhouse correction was applied

Via the 2AR-cAMP-PKA/NF-B pathway, PAGln promotes inflammatory cytokine transcription, as evidenced by increased NF-B phosphorylation and pro-inflammatory macrophage polarization in murine BMDMs following 24-h treatment with 100 M PAGln (Huang and Zhang, 2023)

Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig