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Summary of laboratory model and mechanistic signaling observations Data from documented laboratory peptide signaling studies Documented interactions in GH secretagogue research models Peak elevation in research models Teichman et al., 2006 Reduced time to peak GH pulse Bowers et al., 1991 Physiologic rhythm maintenance Teichman et al., 2006 Verified in laboratory settings Raun et al., 1998 GH secretagogue research suggests pathway activity that supports protein synthesis and lipid oxidation modeling

Tirzepatide produced greater weight loss than semaglutide across all dose comparisons

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We acknowledge the contribution of Huang Jishu from East China of Architectural Design & Research Institute in the beautification of the images in this article

doi: 10.3390/ijms24098447 43 MaiwormM