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No comprehensive, long-term human safety studies have been published

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However, these observations have not been replicated in nonhuman primates or humans and are believed to be a rodent phenomenon due to the higher density of GLP-1R on rodent C cells, so the responses obtained on rodents may not be relevant to primates (Samson and Garber, 2013

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Adenoviral intramyocardial VEGF-DNC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up