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A Hankel singular value decomposition (HSVD) filter(Barkhuijsen et al., 1987) was applied to remove residual water signals and to reduce baseline roll

Both of which regulate mitochondrial biogenesis and shift substrate utilization from glucose toward fatty acid oxidation

Known as the bloodbrain barrier (BBB), this extraordinary and intricate biological construct stands as a highly selective and protective threshold that demarcates the juncture between the periphery and CNS (Figure 1)

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