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No severe side effects occurred, and there were no signs of fat rebound during the 4-week placebo follow-up
Nanoencapsulation allows the co-delivery of synergistic agents, such as GPX4 inhibitors (RSL3, FIN56), iron donors, and lipid peroxidation amplifiers, at reduced individual doses to circumvent toxicity thresholds and overcome resistance mechanisms [102, 103]
Angold A, Costello EJ, Worthman CM
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The REDEFINE 1 Phase 3 trial (Garvey et al., 2025) provides the closest analog for combination tolerability
Rubino D, et al
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