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A clinical trial of once-weekly TZT in T2DM patients illustrated that at 26 weeks of treatment, TZT led to the significant reduction of intercellular adhesion molecule 1 (ICAM-1), growth differentiation factor 15 (GDF-15), chitosan-3 like protein 1 (YKL-40), leptin and CRP compared to the baseline values
Quality assessment The methodological quality of the included studies was evaluated using the Newcastle-Ottawa Scale (NOS) [24], which assesses three domains: selection of study participants, comparability between groups, and the ascertainment of exposure or outcomes, with a maximum achievable score of 9 points
Acute kidney injury and adverse renal events in patients receiving SGLT2-inhibitors: A systematic review and meta-analysis
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Continued research will clarify the long-term effects of these therapies on cirrhosis risk and liver-related mortality, paving the way for new standards in MASLD and MASH care
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