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What NOT to expect in the first 3 nights: Sedation (DSIP is not a sedative a drugged or groggy feeling is a signal to check the dose) Complete resolution of chronic insomnia (sleep architecture remodeling takes longer) Stress or cortisol changes (HPA axis modulation requires sustained dosing) Administration timing: Community protocols describe subcutaneous DSIP 30-60 minutes before the intended sleep time
For this reason, many experimental studies specify the copper-complexed form rather than the free tripeptide when investigating biological activity
(PubMed) Campone M, Berton-Rigaud D, Joly-Lobbedez F, et al
Only 15 calories per serving with no sugar
doi:10.1128/AAC.01446-21 68
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