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Camptothecin (CPT) is a potent anticancer natural compound extracted from the bark of Camptotheca acuminata, which exerts antitumor activity by inhibiting DNA topoisomerase I (Topo I) (Tai et al., 2019)

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Pegylation extends that window by attaching a polyethylene glycol chain to the peptide backbone, slowing renal clearance and giving researchers a longer usable window for site-specific study designs without eliminating the localized character of the response

Attorneys representing those harmed by the drug say the test, which is expensive and prohibitive, is not necessary

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