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Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established

The erythrocytes are capable of reducing metHb to functional Hb through methemoglobin reductases and of detoxifying the cell from H 2 O 2 through the glutathione metabolism [2]

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Severe hypoglycaemia indicates clearly that the insulin dose is too high requiring a more substantial correction

Cholelithiasis (gallstones) like GLP-1, due to rapid weight loss

This phenomenon, referred to as insulin resistance, features elevated glucose and insulin levels in the bloodstream (Rosalyn and Solomon, 1960