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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

Recalculating doses after any protocol change ensures accuracy continues

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Allison Whitten AstraZeneca reports mixed Phase 3 results across oncology and rare disease AstraZeneca reported mixed late-stage clinical results, with its Claudin 18.2-targeting antibody-drug conjugate sonesitatug vedotin meeting its primary endpoint in patients with previously treated advanced gastric cancer, while rare disease therapy Ultomiris missed the primary endpoint in a Phase 3 trial for thrombotic microangiopathy following haematopoietic stem cell transplantation (HSCT-TMA)

Pathogenic Role of the CXCL16-CXCR6 Pathway in Rheumatoid Arthritis

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